Brain Cancer @ Leeds

Dr Georgia Mavria – Group Leader

Contact information
Research
Resume
Grants awarded
Professional activities
Teaching
Publications
PhD and Intercalating students

Contact information

Dr Georgia Mavria
Deputy Head of Section of Brain Tumour Research
Group Leader, Signal Transduction and Cancer Microenvironment Group
Leeds Institute of Cancer and Pathology
Wellcome Trust Brenner Building
St James’s University Hospital
Leeds, LS9 7TF
United Kingdom
Tel: +44(0) 113 343 843
Email: g.mavria@leeds.ac.uk

Research

We are interested in understanding the dependency of brain cancer stem cells on the tumour microenvironment and key signaling pathways activated in response to this interaction that promote growth, invasion and resistance to therapy. We employ state-of-the art organotypic co-culture models combined with cell imaging techniques, genetic deletion approaches and in vivo models of human cancer including patient-derived cancer stem cell models.

Resume

Dr Georgia Mavria studied Biochemistry and Genetics at the University of Leeds where she received a University Research Scholarship to conduct her postgraduate studies investigating mechanisms of regulation of gene expression in the central nervous system. She moved to the National Institute of Medical Research, London (now part of the Francis Crick Institute) as postdoctoral fellow and then to the Institute of Cancer Research (ICR) and the laboratory of the late Professor Chris Marshall where she developed her interest in signal transduction and the role of the tumour microenvironment, and led the Signalling in Angiogenesis team as an independent scientist. Dr Mavria moved back to the University of Leeds in 2009 as a BHRC Translational Research Fellow and was awarded tenure in 2015. Dr Mavria’s cancer research is focused on investigating signal transduction pathways in the microenvironment of brain tumours.

Grants awarded

2016-2019 Breast Cancer Now Investigating the role of the guanine nucleotide exchange factor DOCK4 in the
development and growth of brain metastases
£198,000
2015-2018 BHF Characterising the in vitro and in vivo roles of the small GTPase RhoG in regulating
angiogenesis
£110,000
2012-2013 Breast Cancer Now Elucidating the role of DOCK4 in the microenvironment of breast cancer brain
metastases using genetic deletion analyses
£19,000
2012-2013 Leeds CRUK Centre Elucidating the role of novel regulators of angiogenesis in the microenvironment of brain tumours
£24,000
2010-2013 Yorkshire Cancer Research Regulation of Rho family GTPases and guanine nucleotide exchange factors in cancer
angiogenesis
£231,000
2009-2014 University of Leeds Senior Translational Research Fellowship
2010-2011 Wellcome Trust Value in people award
£19,000
2007-2010 Cancer Research UK Identification of Rho-family GTPases and regulatory proteins required for tumour
angiogenesis
£198,000


Professional activities

Teaching

Publications

Grant, M., Grant, G. and Mavria, G. (2016). Assessing the components of a novel VEGF signalling cascade as potential prognostic markers in glioblastoma (P5. 253). Neurology 86(suppl 16), P5-253.

Abraham S, Scarcia M, Bagshaw RD, McMahon K, Grant G, Harvey T, Yeo M, Esteves FO, Thygesen HH, Jones PF, Speirs V, Hanby AM, Selby PJ, Lorger M, Dear TN, Pawson T, Marshall CJ and Mavria G (2015). A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis Nat Commun. 6, 7286.

Nash C, Mavria G, Baxter E, Holliday D, Treanor D, Tomlinson D, Novistkaya V, Hanby A, Berditchevski F, Speirs V. (2015). Development and characterisation of a 3D multi-cellular in vitro model of normal human breast: a tool for cancer initiation studies. Oncotarget 6, 13731-41.

Kaur S, Leszczynska K, Abraham S, Scarcia M, Hiltbrunner S, Marshall CJ, Mavria G, Bicknell R, Heath VL (2011). RhoJ/TCL regulates endothelial motility and tube formation and modulates actomyosin contractility and focal adhesion numbers Arterioscler Thromb Vasc Biol. 31, 657-64.

Hetheridge C, Mavria G*, Mellor H. (2011). Uses of the in vitro endothelial-fibroblast organotypic co-culture assay in angiogenesis research. Biochem Soc Trans. 39, 1597-600.

Abraham S, Yeo M, Montero-Balaguer M, Paterson H, Dejana E, Marshall CJ, Mavria G (2009).VE-cadherin suppresses sprouting via signalling to MLC2 phosphorylation Curr Biol. 19, 668-74.

Mavria G, Abraham S, Yeo M and Marshall CJ (2008). Role of MAP-kinase, RhoGTPases and actomyosin contractility in endothelial cell migration and vessel establishment. FASEB Journal 22, 611.

Mavria G*, Vercoulen Y, Yeo M, Paterson H, Karasarides M, Marais R, Bird D, Marshall CJ* (2006).ERK-MAPK signalling opposes Rho-kinase to promote endothelial cell survival and sprouting during angiogenesis Cancer Cell. 9, 33-44.

Gonzalez-Garcia A, Pritchard CA, Paterson HF, Mavria G, Stamp G, Marshall CJ (2005) RalGDS is required for tumour formation in a model of skin carcinogenesis. Cancer Cell. 7, 219-26.

Croft DR, Sahai E, Mavria G, Li S, Tsai J, Lee W, Marshall CJ, Olson MF (2004) Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis Cancer Res. 64, 8994-9001.

For more publications see: http://medhealth.leeds.ac.uk/profile/900/767/dr_georgia_mavria/publications

PhD and Intercalating students

Teklu Egnuni (co-supervisor Prof Susan Short). Development of a 3D organotypic model of the human brain perivascular niche: studies of the effects of radiotherapy on the niche and interaction with cancer stem cells

Leander Stewart (co-supervisor Dr Stephen Wheatcroft). Characterising the in vitro and in vivo roles of the small GTPase RhoG in regulating angiogenesis

Gary Grant (co-supervisor Prof Colin Johnson). Rho GTPase signalling and ciliary function in normal and pathological endothelial cell biology

Joanne Topping (lead supervisor Dr Carmel Toomes). Investigating angiogenesis pathways in cancer

If you are interested in a PhD in my laboratory, please contact me directly to discuss opportunities: g.mavria@leeds.ac.uk

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