Brain Cancer @ Leeds

Dr Anke Brüning-Richardson – Senior Research Fellow

Contact Information

Dr Anke Brüning-Richardson
Senior Research Fellow
Leeds Institute of Cancer and Pathology
Wellcome Trust Brenner Building
St James University Hospital
Beckett St
Leeds
LS9 7TF

tel: 0113 343 7853
email: bgyar@leeds.ac.uk

Resume

Research

My research focuses on mechanisms of cell migration and targeting the migratory/invasive behavior of cancer cells. Currently funded by the PPR Foundation to research cell migration in Glioblastoma multiforme, the most aggressive form of malignant primary brain tumours, my research includes large scale drug screens of novel therapeutics targeting Glycogen synthase kinase 3 (GSK-3) and determining the mechanisms of drug activity on cell migration. This involves the application of various cell-biology based techniques including live cell imaging. I am also interested in the role of receptor signaling and epigenetics in glioma cell migration. Current research has focused on the role of FGFR1 signalling in paediatric gliomas and the effect of the HDAC inhibitor MI-192 on cell migration and differentiation in adult and paediatric gliomas.

Past Highlights

I am also interested in the advancement and development of diagnostic tests and therapeutic agents in the veterinary and medical field. This has led to the development of rapid diagnostic strip-tests for the pen-side diagnosis of viral infections of veterinary importance. I developed the commercially available rinderpest detection test (Svanova Biotech AB product RPV-Ag 10-4300-13), which played an integral part in the global rinderpest eradication, and participated in the development of the commercially available foot and mouth disease test.

Other Interests

I am actively involved in public engagement activities. I am a Leeds Champion of Public Engagement (pepNet) and have won several public engagement awards and grants.

Teaching

I am academic co-lead for the Extended Student-led Research and Evaluation project (ESREP) module, an integral part of the MBChB Medicine undergraduate course at the University of Leeds. I am also course supervisor for RESS-1SSP (first year medical degree) research projects.

Recent winners of bursary awards for student presentation at national conferences include:

Publications

Book chapters and reviews

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