Brain Cancer @ Leeds

Dr Mihaela Lorger – Group Leader

Contact Information

Dr Mihaela Lorger
Lecturer
Leeds Institute of Cancer and Pathology
Wellcome Trust Brenner Building
St James’s University Hospital
LS9 7TF, Leeds
United Kingdom

tel: +44 (0) 113 343 8449
email: M.Lorger@leeds.ac.uk

Overview

Dr. Lorger received her PhD degree from the Technical University of Darmstadt in Germany. She did her postdoctoral training at the University of Zurich in Switzerland where she investigated the role of cell-junction protein in the transformation of mammary cells. She then moved to the Scripps Research Institute in California as a postdoctoral fellow funded by the Susan G Komen Breast Cancer Research Organisation, where she studied the biology of brain metastases. Dr. Lorger started her independent academic career in January 2011 and was tenured in 2016. Her research group is investigating the role of tumour microenvironment in the brain, with a particular focus on the inflammatory cells. For more on the Brain Metastasis group click here.

Publications

Rippaus N., Taggart D., Williams J., Andreou T., Wurdak H., Wronski K., Lorger M. (2016) Metastatic site-specific polarization of macrophages in intracranial breast cancer metastases. Oncotarget 2016 May 18. doi: 10.18632/oncotarget.9445. [Epub ahead of print]

Weber M.R., Zuka M., Lorger M., Tschan M., Torbett B.E., Zijlstra A., Quigley J.P., Staflin K., Eliceiri B.P., Krueger J.S., Marchese P., Ruggeri Z.M., Felding-Habermann B. (2016) Activated tumor cell integrin αVβ3 cooperates with platelets to promote extravasation and metastasis from the blood stream. Thrombosis Research 2016 Apr; 140 Suppl 1:S27-36.

Abraham S, Scarcia M, Bagshaw RD, McMahon K, Grant G, Harvey T, Yeo M, Esteves FO, Thygesen HH, Jones PF, Speirs V, Hanby AM, Selby PJ, Lorger M, Dear TN, Pawson T, Marshall CJ, Mavria G. (2015) A Rac Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis. Nat communications 2015 Jul 1;6:7286.

Lorger M (2012) Tumor microenvironment in the brain. Cancers, 4 (1), pp. 218-243.

Lorger M; Lee H; Forsyth JS; Felding-Habermann B (2011) Comparison of in vitro and in vivo approaches to studying brain colonization by breast cancer cells. J Neurooncol, 104 (3), pp. 689-696.

Lorger M; Felding-Habermann B (2010) Capturing changes in the brain microenvironment during initial steps of breast cancer brain metastasis. Am J Pathol, 176 (6), pp. 2958-2971.

Staflin K; Krueger JS; Hachmann J; Forsyth JS; Lorger M; Steiniger SC; Mee J; Pop C; Salvesen GS; Janda KD; Felding-Habermann B (2010) Targeting activated integrin alphavbeta3 with patient-derived antibodies impacts late-stage multiorgan metastasis. Clin Exp Metastasis, 27 (4), pp. 217-231.

Wurdak H; Zhu S; Romero A; Lorger M; Watson J; Chiang CY; Zhang J; Natu VS; Lairson LL; Walker JR; Trussell CM; Harsh GR; Vogel H; Felding-Habermann B; Orth AP; Miraglia LJ; Rines DR; Skirboll SL; Schultz PG (2010) An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation. Cell Stem Cell, 6 (1), pp. 37-47.

Lorger M; Krueger JS; O’Neal M; Staflin K; Felding-Habermann B (2009) Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brain. Proc Natl Acad Sci U S A, 106 (26), pp. 10666-10671.

Baumgartner M; Radziwill G; Lorger M; Weiss A; Moelling K (2008) c-Src-mediated epithelial cell migration and invasion regulated by PDZ binding site. Mol Cell Biol, 28 (2), pp. 642-655.

Keyser J; Lorger M; Pavlovic J; Radziwill G; Moelling K (2007) Role of AF6 protein in cell-to-cell spread of Herpes simplex virus 1. FEBS Lett, 581 (28), pp. 5349-5354.

Lorger M; Moelling K (2006) Regulation of epithelial wound closure and intercellular adhesion by interaction of AF6 with actin cytoskeleton. J Cell Sci, 119 (Pt 16), pp. 3385-3398.

Homann M; Lorger M; Engstler M; Zacharias M; Göringer HU (2006) Serum-stable RNA aptamers to an invariant surface domain of live African trypanosomes. Comb Chem High Throughput Screen, 9 (7), pp. 491-499.

Göringer HU; Homann M; Lorger M (2003) In vitro selection of high-affinity nucleic acid ligands to parasite target molecules. Int J Parasitol, 33 (12), pp. 1309-1317.

Lorger M; Engstler M; Homann M; Göringer HU (2003) Targeting the variable surface of African trypanosomes with variant surface glycoprotein-specific, serum-stable RNA aptamers. Eukaryot Cell, 2 (1), pp. 84-94.

 

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